Why These 11 Ingredients Are Redefining Longevity
Longevity is no longer about living longer at any cost. It’s about extending the years in which we feel strong, sharp and capable. The pursuit of healthy ageing has shifted from chasing miracle cures to embracing compounds with real, peer-reviewed science behind them.
At Verve, we’ve curated eleven clinically-studied ingredients that work at the cellular level to support energy, focus, resilience and healthy ageing. Each is chosen for its unique mechanism of action and potential to complement one another within a holistic longevity routine.
This is what’s driving the next wave of human performance.
1. Sulforaphane - Cellular Defence from Within
Found naturally in cruciferous vegetables such as broccoli sprouts, sulforaphane is one of the most powerful natural activators of the body’s detoxification and antioxidant pathways. Studies show that sulforaphane triggers Nrf2, a transcription factor that regulates over 200 genes involved in antioxidant protection, inflammation control and cellular repair.
For those seeking to stay sharp and energised as they age, sulforaphane helps reduce oxidative stress and support brain and cardiovascular health. Regular intake can help cells respond better to everyday stressors, allowing the body to maintain resilience over time.
2. Ca-AKG - Energy for the Long Haul
Calcium Alpha-Ketoglutarate (Ca-AKG) is gaining attention for its potential role in supporting healthy ageing. As a key intermediate in the Krebs cycle, it fuels mitochondrial energy production and supports protein synthesis.
Research from the Buck Institute for Research on Ageing suggests that Ca-AKG may influence pathways linked to inflammation and cellular ageing, helping maintain metabolic balance as we grow older. By supporting collagen synthesis, it may also contribute to stronger connective tissues and skin vitality.
For those who want to feel as strong and focused at 50 as they did at 30, Ca-AKG helps sustain that cellular energy foundation.
3. NMN - Recharging the NAD+ System
Nicotinamide Mononucleotide (NMN) is a direct precursor to NAD+, a vital molecule involved in energy metabolism and DNA repair. NAD+ levels naturally decline with age, leading to lower energy and reduced cellular resilience.
Supplementing with NMN has been shown to increase NAD+ levels, improving mitochondrial efficiency and supporting overall metabolic health. The result is improved vitality and recovery - something that anyone striving for peak performance can feel.
4. TMG - The Quiet Supporter of Methylation
Trimethylglycine (TMG), or betaine, is often overlooked but plays an essential role in methylation, a biochemical process that affects everything from energy production to gene expression. Methylation efficiency tends to decline with age, but maintaining it supports cardiovascular health, detoxification and cognitive performance.
By donating methyl groups, TMG works synergistically with NMN to maintain optimal NAD+ cycling, supporting both energy and longevity from the inside out.
5. Quercetin + Fisetin - Nature’s Senolytics
Cellular ageing isn’t just about slowing down damage; it’s also about clearing away what no longer serves us. Quercetin and fisetin are flavonoids that act as senolytics - compounds that help the body clear out senescent cells, those “zombie” cells that accumulate with age and disrupt healthy tissue.
Both ingredients are rich in antioxidant and anti-inflammatory properties. Together, they may support clearer skin, better recovery and sharper cognitive function by helping tissues regenerate more efficiently.
6. Astaxanthin - The Antioxidant Powerhouse
Often referred to as the “king of carotenoids”, astaxanthin is a natural pigment found in microalgae and salmon. It is one of the most potent antioxidants known, shown to be up to 6000 times more powerful than vitamin C in neutralising free radicals.
Beyond its antioxidant strength, astaxanthin supports skin elasticity, muscle endurance and eye health. It protects cell membranes from oxidative stress, a key factor in visible and internal ageing. Regular supplementation helps maintain a healthy glow, inside and out.
7. PQQ - Mitochondrial Renewal
Pyrroloquinoline Quinone (PQQ) supports mitochondrial biogenesis - the creation of new mitochondria within cells. Since mitochondria are the engines of our energy production, this means PQQ plays a crucial role in maintaining long-term vitality.
Peer-reviewed research suggests PQQ may also support cognitive health by improving mitochondrial function in the brain. It’s an ideal compound for those seeking better energy, focus and mental clarity throughout the day.
8. Spermidine - Autophagy Activation
Spermidine is a naturally occurring polyamine that has been studied for its role in autophagy - the process by which cells recycle damaged components. This cellular “spring cleaning” is essential for longevity and metabolic balance.
By promoting autophagy, spermidine helps cells stay efficient and resilient, supporting heart health, metabolic function and cognitive performance. For anyone looking to age well, this mechanism is fundamental.
9. Berberine 150mg + ALA – Metabolic Balance
Berberine is a plant alkaloid that supports glucose metabolism and insulin sensitivity, offering benefits similar to those of metformin in some studies. Combined with alpha-lipoic acid (ALA), it provides additional antioxidant support while enhancing mitochondrial energy production.
Together, these compounds promote balanced blood sugar levels, improved metabolic flexibility and sustained energy - crucial factors for those pursuing longevity through metabolic health.
10. Apigenin - Hormone and Sleep Support
Found in chamomile and parsley, apigenin is a flavonoid known for its calming, anti-inflammatory and hormone-supportive effects. It helps regulate cortisol levels and supports the body’s natural production of growth hormone - a key player in muscle repair and regeneration.
Apigenin also supports better sleep quality - a cornerstone of longevity that underpins every other physiological process. Consistent, restorative rest helps the body repair and rebuild daily.
11. Resveratrol Balance - A Measured Approach to Anti-Ageing
Resveratrol, the polyphenol found in red grapes and berries, activates sirtuins, a group of proteins linked to DNA repair and cellular longevity. It’s often referred to as the “red wine molecule”, though effective doses require more than diet alone can provide.
Our balanced approach to resveratrol ensures the right concentration without overwhelming the system, allowing it to work synergistically with NMN and Ca-AKG for optimal NAD+ and sirtuin activation.
Building Longevity Through Consistency
The science behind longevity is clear: the real results come from consistency. The compounds above don’t offer overnight transformation - they work gradually, improving cellular efficiency and resilience over time.
For anyone serious about performance and healthy ageing, daily consistency is non-negotiable. That’s why a subscription model makes sense - it keeps your routine seamless, your ingredients replenished and your results compounding.
Longevity isn’t a quick fix. It’s a daily investment in your future self.
The Future of Performance and Healthy Ageing
These 11 ingredients represent the intersection of cellular science and practical performance. They don’t chase fads or empty promises. Each is backed by decades of peer-reviewed research, chosen to support the body’s innate capacity to renew, repair and thrive.
At Verve, we believe in precision, not excess. Quality, not quantity. And most importantly, consistency.
Your best years aren’t behind you - they’re ahead. And they start at the cellular level.